We find that we not only ignore the beginning and end of the world, but coincidentally have the same ignorance of the beginning and purpose of knowledge. The ignorance of the world has features in common with the ignorance of ourselves and the purpose of our choices and efforts. And our ignorance of the world and of ourselves is also linked to our ignorance of the deficiency of knowledge. With this ignorance of ignorance we feel familiar with the world and live as if the whole world were present in our eyes. Ignorance of the world, ignorance of the purpose of knowledge and life, ignorance of ourselves, and ignorance of the deficiency of knowledge seem to be the same ignorance. This ignorance creates the illusion that we have enough knowledge of all of them. If we were fully aware of the world, then we would probably be fully aware of ourselves as well. But we probably wouldn't be who we are now (in time and space). These rational thoughts quickly reveal a closer connection between the world, life, information and self-knowledge. Each one of them depends on the other.

Some issues that are even in opposite direction of research are rationally inseparable:

1) What is the world, if it has a beginning and an end and what are its limits. (Cosmological issue).

2) What is knowledge, how does knowledge begin, if knowledge comes to an end and what does it serve. (Gnoseology).

3) What we are, generally what life is and what we ask for. (Moral and psychological issue).